Swiss Study Reveals: Coronavirus Attacks Lining Of Blood Cells And Not Just Lungs

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ZURICH (VINnews) — A new Swiss study published in the prestigious medical journal The Lancet claims that coronavirus does not just harm lungs but also attacks the lining of blood vessels all over the body, ultimately leading to multiple organ failure.

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“This virus does not only attack the lungs, it attacks the vessels everywhere,” said Frank Ruschitzka, an author of the paper from University Hospital Zurich. He added that researchers had found that the deadly virus caused more than pneumonia.

“It enters the endothelium [layer of cells], which is the defence line of the blood vessels. So it brings your own defence down and causes problems in microcirculation,” said Ruschitzka, referring to circulation in the smallest of blood vessels.

It then reduces the blood flow to different parts of the body and eventually stops blood circulation, according to Ruschitzka, chairman of the heart centre and cardiology department at the university hospital in Switzerland.

“From what we do see clinically, patients have problems in all organs – in the heart, kidney, intestine, everywhere,” he said.

Ruschitzka also explained based on his hypothesis why smokers and people with pre-existing conditions who had a weakened endothelial function, or unhealthy blood vessels, were more vulnerable to the novel coronavirus. Those underlying conditions included hypertension, or high blood pressure, diabetes, obesity and established cardiovascular disease.

The study, published last Friday, detected viral elements within endothelial cells, which line the inside of blood vessels, and inflammatory cells in Covid-19 patients.

The results of the study were based on an analysis of just three cases, but Ruschitzka said autopsies on other Covid-19 patients had also found that their blood vessel linings were “full of virus” and the function of vessels was impaired in all of their organs.

One of the cases was a 71-year-old Covid-19 patient with coronary artery disease and arterial hypertension who had developed multisystem organ failure and died, according to the study.

A postmortem analysis of his transplanted kidney showed viral structures in the endothelial cells. Researchers also found inflammatory cells in the heart, small bowel and lungs, where most small vessels appeared congested.

Another 58-year-old patient with diabetes, arterial hypertension and obesity developed mesenteric ischemia, or decreased blood flow to the small intestine that can permanently damage the organ. Lymphocytic endothelitis, which causes inflammation of the endothelium, was also found in her lungs, heart, kidneys and liver..

On top of a vaccination that reduces virus replication, Ruschitzka suggested strengthening vascular health may be key to treating Covid-19 patients.

“All patients who are at risk and the elderly should be treated very well for the underlying cardiovascular conditions. The better they are treated, the more likely they are to survive the Covid-19 infection,” he said.

“We know that angiotension-converting enzyme inhibitors [heart medications used to treat high blood pressure] and anti-inflammatory drugs [make the endothelium stronger],” he said.

John Nicholls, a clinical professor in pathology at the University of Hong Kong, said more research was needed.

“While many structures may seem to resemble viral particles using the electron microscope, other laboratory techniques should be done to confirm true viral infection,” he said.


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