JERUSALEM (JNS) – Scientists at Ben-Gurion University of the Negev in Beersheva and their colleagues at Sichuan University in Chengdu and the National University of Singapore have identified a naturally occurring molecule that reduces the biofilm that produces plaque and causes cavities.
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The researchers found that the molecule 3,3′-Diindolylmethane (DIM), also known as bisindole, disrupted biofilm formation by 90% and therefore bacteria such as Streptococcus mutans were not given a chance to grow and attack enamel.
The findings were published earlier this month in the journal Antibiotics.
“The molecule, which was found to have low toxicity, could be added to toothpastes and mouthwashes to greatly improve dental hygiene,” said lead author Professor Ariel Kushmaro of the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering at Ben-Gurion.
Kushmaro is also a member of the Ilse Katz Institute for Nanoscale Science and Technology and the Goldman Sonnenfeldt School of Sustainability and Climate Change.
The study was conducted with Kushmaro’s student Yifat Baruch along with Dr. Karina Golberg and Professor Robert S. Marks, as well as Qun Sun of Sichuan University and Karina Yew-Hoong Gin of the National University of Singapore.
the big question is, can the bacteria develop resistance. because trislocan was the last wonder drug for dental plaque and…
Because of potential health concerns, due to the possibility of antimicrobial resistance, endocrine disruption and other issues as listed below, triclosan has been designated as a “contaminant of emerging concern (CEC)”
Excerpt from Wikipedia: Diindolylmethane (DIM) is found in cruciferous vegetables, such as broccoli, brussels sprouts, cabbage, and kale….. ….. – they are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms